1 milligram for 550 EURO !!
IST-9 mAb reacts both with sections from frozen and paraformaldehyde fixed tissues.
IST-9 reacts with the C’-C’ loop of ED-A preventing ED-A binding with integrins alpha5-beta1, alpha4-beta1 and alpha9-beta1. IST-9 inhibits fibroblasts differentiation into myo-fibroblasts and TGF-beta activation, thus inhibiting fibrosis (see under the Antibodies section).
More recently it has been demonstrated that the ED-A FN is selectively induced during lymphocytes TH1 differentiation and is constitutively expressed by highly polarized TH1 cells (Sandig H. et al. J Allergy Clin Immunol 124:528-35, 2009).
IST-9 has bee generated in the laboratory of one of the founders of Sirius-biotech.