Special offer of the mAb IST-9 specific for ED-A of fibronectin

By : June 1, 2011

 1 milligram for 550 EURO !!

IST-9 mAb reacts both with sections from  frozen and paraformaldehyde fixed tissues.

IST-9 reacts with the C’-C’ loop of  ED-A preventing ED-A binding with integrins alpha5-beta1, alpha4-beta1 and alpha9-beta1. IST-9 inhibits fibroblasts differentiation into myo-fibroblasts and TGF-beta activation, thus inhibiting fibrosis (see under the Antibodies section).

More recently it has been demonstrated that the ED-A FN is selectively induced during lymphocytes TH1 differentiation and is constitutively expressed by highly polarized TH1 cells (Sandig H. et al. J Allergy Clin Immunol 124:528-35, 2009).

Section from paraffin embedded human melanoma SK-MEL-28 stained with IST-9 mAb.

Section from paraffin embedded human melanoma SK-MEL-28 stained with the mAb IST-9.

                                                  

 

IST-9 has bee generated in the laboratory of one of the founders of  Sirius-biotech.

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