Discovered and localized a novel fibronectin tumor associated epitope

Discovered and localized a novel fibronectin oncofetal epitope.

This epitope is recognized by the mAb C6 that, in addition to providing a new reagent for angiogenesis targeting, represents a new tool for the study of the potential biological functions of fibronectin.

Ventura et al.  (2010) “Alternative splicing of the angiogenesis associated extra-domain B of fibronectin regulates the accessibility of the B-C loop of the type III repeat 8.” PLos ONE 5(2):e-9145.

Structural comparison of the interface between the FNIII 7/FN III8 and between the ED-B/FNIII 8 domains by superimposition of structures of the ED-B with FNIII 7. Ventura et al. 2010 adapted from Fattorusso et al. (1999) Structure 7:381-390.